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Alternative rodent handling methods and their impact in research
Presenters: Dr. Rachael N. Labitt & Dr. Thomas D. Prevot
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| Mouse handling and restraint has an impact on behavior, physiology and animal welfare, yet there is little data on the effect of mouse restraint method on cardiovascular parameters. We validated the use of a smartphone-based ECG system in mice by performing simultaneous smartphone and telemetry ECG recordings in conscious, restrained mice, and in anesthetized mice. |
 Dr. Rachael N. Labitt Center for Animal Resources and Education, Cornell University, College of Veterinary Medicine, Ithaca, NY |
Dr. Rachael Labitt is a rodent facility veterinarian at the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health in Bethesda, Maryland. Prior to starting at NICHD in August 2020, she completed a residency in laboratory animal medicine at Cornell University’s Center for Animal Resources and Education and a master’s degree in a fish microbiology lab. Prior to earning her DVM also at Cornell University, she earned her bachelor’s degree at Dartmouth College, where she was first introduced to the wonders of mice. She worked for two years as a research assistant in Charlie Rice’s virology laboratory at The Rockefeller University, where she decided that mice were definitely the best. Dr. Labitt’s interests include animal welfare, mouse health, and antibiotic resistance. |
| Current research including the use of rodents assumes that mice and rats differ to a certain extent in their ability to habituate to human manipulations and handling. While rats appear to habituate well to human interaction, mice are known to be more consistently reactive, making them difficult to work with. |
 Dr. Thomas D. Prevot Project Scientist, Campbell Family Mental Health Research Institute of CAMH, Centre for Addiction and Mental Health, Toronto. And Assistant Professor, Department of Psychiatry, University of Toronto, Toronto, ON, Canada |
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Dr. Prevot received his PhD in Behavioral Neuropsychopharmacology from the University of Bordeaux in France in 2015, and started his postdoctoral fellowship in CAMH in 2016. In 2019, he became a project scientist in CAMH, and an Assistant Professor in the Department of Psychiatry of the University of Toronto. He now leads a Drug Development Program at CAMH with the ultimate goal of developing novel therapeutic avenues for the treatment of depression and age-related cognitive decline. Dr. Prevot’s research focuses on the neurobiology of stress, aging and their interactions, and on understanding how they impact quality of life, leading to psychiatric and neurodegenerative diseases. As a behavioral pharmacologist, he has developed a unique expertise in the field of translational research, including the characterization of novel targets for therapeutic avenues and medication development for future clinical testing. Dr. Prevot is actively involved in the translational research and medicine landscape at the University of Toronto, working across disciplines and being an advocate for bench-to-bedside discovery. |
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