Using the Zebrafish Model to Understand Vascular Biology and Human Stroke

Dr. Sarah Childs,  Associate Professor, Biochemistry & Molecular Biology, AHFMR Senior Scholar; Canada Research Chair (Tier II – Genetics/Angiogenesis)

Abstract to come.





About the Speaker...

The Childs lab is interested in the development of the vascular system, neural crest and eye, and in determining the genes that drive normal development as well as the mechanisms by which mutations in key genes result in defects using the zebrafish model. Dr. Childs undertook her PhD at the University of Toronto, before moving to the BC Cancer Research Centre and Harvard Medical School for postdoctoral work. In Boston, she joined the rapidly growing field of zebrafish research, taking part in some of the first genetic screens for defects in cardiovascular development.

Since moving to the University of Calgary in 2001, she has been instrumental in discovering signals for normal vascular patterning, angiogenic growth  and vascular stabilization by studying the genetics of endothelial and smooth muscle cells. .

Each of these projects uses the zebrafish as a genetic model to probe pathways, starting from a gene essential for normal development and connecting interacting genes to understand cellular mechanisms. The lab also has a strong interest in connecting basic research in the zebrafish model to human genetic disease by using the zebrafish to model rare human diseases.

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